Quantitative Tractography and Volumetric MRI in Blast and Blunt Force TBI: Predictors of Neurocognitive and Behavioral Outcome
Abstract
The major goals and aims of this study are to investigate whether differences in cognitive outcome are related to mechanism of injury as well as white matter integrity using diffusion tensor imaging (DTI). We are also collecting and analyzing data in order to determine whether MR variables of interest are associated with psychosocial/clinical outcome, and whether there are group differences by mechanism of injury. Specifically, in the context of this study, we use novel, sophisticated MRI methods (e.g., quantitative diffusion tensor [DT] tractography) in order to characterize white matter changes seen within and across TBI subtypes, identify those at highest risk for poor outcomes, and gain knowledge about potential interventions to aid in recovery of brain functioning and cognition. In addition, we seek to identify the unique psychosocial challenges posed by differing mechanisms of injury as well as investigate the contribution of genetic factors(Apolipoprotein-E epsilon-4 [APOE epsilon4] and brain-derived neurotrophic factor [BDNF]) to brain integrity, neuropsychological functioning, and neurobehavioral outcome.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2016
- Accession Number
- AD1035535
Entities
People
- Lisa Delano-wood