Cell Penetrating Bispecific Antibodies for Targeting Oncogenic Transcription Factors in Advanced Prostate Cancer

Abstract

The goal of these studies is to develop and validate cell-penetrating bi-specific antibodies as an agent that can selectively inhibit the function of intracellular proteins. We have developed 3E10-AR441 bi-specific antibody to inhibit the function both ligand-dependent and independent forms of the androgen receptor (AR), key drivers of prostate carcinogenesis.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2016
Accession Number
AD1035710

Entities

People

  • Michael Lilly
  • Richard Weisbart

Organizations

  • Medical University of South Carolina

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Androgens
  • Antibodies
  • Biomedical Research
  • Blood Proteins
  • Cell Line
  • Cells
  • Confocal Microscopy
  • Detection
  • Fungi
  • Medical Personnel
  • Molecules
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Standards

Fields of Study

  • Biology
  • Medicine

Readers

  • Oncology
  • Prostate Cancer Biology.