Prediction of Response to Therapy and Clinical Outcome through a Pilot Study of Complete Genetic Assessment of Ovarian Cancer

Abstract

In this project low grade serous cancer, clear cell, endometrioid (low grade and high grade),and mucinous cancers will be interrogated and subjected to somatic mutation profiling using genome sequencing and array comparative genomic hybridization (aCGH) to explore copy number alterations (CNA). To date, over 200subjects have enrolled and pathology has identified blocks for DNA extraction. The Study remains important as nothing has been published on the molecular alternation of the different histological subtypes of ovarian cancer.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2015
Accession Number
AD1035711

Entities

People

  • Ursula Matulonis

Organizations

  • Dana–Farber Cancer Institute

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Cells
  • Department Of Defense
  • Extraction
  • Genetic Phenomena
  • Health Services
  • Institutional Review Board
  • Lymphocytes
  • Medical Personnel
  • Mutations
  • Neoplasms
  • Oncology
  • Ovarian Cancer
  • Pathology
  • Pilot Studies
  • Statistical Analysis

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology