Pathogenesis and Prediction of Future Rheumatoid Arthritis
Abstract
It is now well established that there is a preclinical period of rheumatoid arthritis (RA)development that is characterized by abnormalities of the immune system prior to the onset of the clinically apparent inflammatory joint disease that currently defines RA. The primary goal of this project is to investigate this preclinical period in order to understand two major factors: 1) how biomarker changes in preclinical RA can be used to accurately predict the future development of RA in currently asymptomatic individuals, and 2) to identify factors related to the pathogenesis of RA that can ultimately be targeted to prevent RA. This project has proposed to use a unique set of serum samples and clinical data available through the Department of Defense Serum Repository (DoDSR) to investigate the preclinical period of RA. During this project, we acquired the serum samples and data from the DoDSR, and completed biomarker testing. Because of delays in obtaining the final data from the DoDSR, we have requested a no-cost extension until 29-Sep-2017 during which final analyses will be performed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2016
- Accession Number
- AD1035721
Entities
People
- Kevin D Deane
Organizations
- Regents of the University of Colorado