Targeting Transcription Elongation Machinery for Breast Cancer Therapy
Abstract
This project focuses on the important but under-studied role of the P-TEFb-dependent transcription elongation machinery in human breast cancer progression. It aims to test the hypothesis that transcription elongation is a key regulatory step in breast cancer development, and that targeting P-TEFb can be an effective strategy to block breast cancer progression. During the current reporting period, we have made significant progress toward the identification of the ELL2-containing SEC as the form of active P-TEFb that plays a key role in promoting breast cancer cell EMT.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2017
- Accession Number
- AD1035753
Entities
People
- Kunxin Luo
Organizations
- University of California, Berkeley