Odor-Evoked Inhibition of Olfactory Sensory Neurons Drives Olfactory Perception in Drosophila

Abstract

Inhibitory response occurs throughout the nervous system, including the peripheral olfactory system. While odor-evoked excitation in peripheral olfactory cells is known to encode odor information, the molecular mechanism and functional roles of odor-evoked inhibition remain largely unknown. Here, we examined Drosophila olfactory sensory neurons (OSNs) and found that inhibitory odors triggered outward receptor currents by reducing the constitutive activities of odorant receptors, inhibiting the basal spike firing in OSNs. Remarkably, this odor-evoked inhibition of OSNs elicited by itself a full range of olfactory behaviors from attraction to avoidance, as did odor-evoked OSN excitation.

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Document Details

Document Type
Technical Report
Publication Date
Nov 07, 2017
Accession Number
AD1035796

Entities

People

  • Bi-yang Jing
  • Chao Tang
  • Dong Yang
  • Dong-gen Luo
  • Li-hui Cao
  • Meng-tong Li
  • Shanshan Qin
  • Wei Wu
  • Xiankun Zeng
  • Yuhai Tu

Organizations

  • Institute of Medical Biology
  • Peking University
  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alkenes
  • Animal Structures
  • Biological Sciences
  • Biology
  • Cells
  • Chemistry
  • Coding
  • Detection
  • Detectors
  • Diptera
  • Drosophila
  • Ear
  • Eigenvalues
  • Equations
  • Fish
  • Free Energy
  • Fungi
  • Insects
  • Ketones
  • Kinetics
  • Molecular Biology
  • Nervous System
  • Neurons
  • Nucleotides
  • Power Spectra
  • Sensory Receptor Cells
  • Steady State

Fields of Study

  • Biology
  • Psychology

Readers

  • Marine Hydrodynamics
  • Neuroscience
  • Vector-Borne Disease and Entomology