Gene Expression Profile of Human Cytokines in Response to B.pseudomallei Infection

Abstract

Melioidosis, is an under-reported infectious disease, caused by the gram-negative bacterium Burkholderia pseudomallei. Understanding disease pathogenesis and susceptibility is crucial for developing newer diagnostic and therapeutic strategies for this life threatening infection. In this study, we aimed to analyze the gene expression levels of important cytokines in melioidosis patients and establish useful correlates with disease biomarkers compared to cases of sepsis infection caused by other pathogens and healthy individuals. A Qiagen common human cytokines array, profiling the gene expression of 84 important cytokines by real time quantitative polymerase chain reaction (RT qPCR) was used.

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Document Details

Document Type
Technical Report
Publication Date
Apr 19, 2017
Accession Number
AD1035802

Entities

People

  • Mohan Natesan

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Bacteria
  • Bacterial Infections
  • Blood
  • Cardiovascular System
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Health Services
  • Lymphocytes
  • Medical Personnel
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Sepsis

Fields of Study

  • Medicine

Readers

  • Microbial Pathology
  • Molecular Genetics
  • Molecular and Cellular Biology