Green-Tea and Epigallocatechin-3-Gallate are Bactericidal against Bacillus anthracis

Abstract

Bacillus anthracis, the etiological agent of anthrax, is listed as a Category A biothreat agent by the United States Centers for Disease Control and Prevention. The virulence of the organism is due to expression of two exotoxins and capsule, which interfere with host cellular signaling, alter host water homeostasis, and inhibit phagocytosis of the pathogen, respectively. Concerns regarding the past and possible future use of B. anthracis as a bioterrorism agent have resulted in an impetus to develop more effective protective measures and therapeutics. In this study, green tea was found to inhibit the in vitro growth of B. anthracis. Epigallocatechin-3-gallate (EGCG), a compound found abundantly in green tea, was shown to be responsible

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Document Details

Document Type
Technical Report
Publication Date
Jun 12, 2017
Accession Number
AD1035806

Entities

People

  • Arthur M. Friedlander
  • Jennifer Chua
  • Maggie C. Shi
  • Shane D. Falcinelli

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • 588839
  • Albumins
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Bacteria
  • Biological Sciences
  • Biological Toxins
  • Biomedical Research
  • Blood
  • Cellular Structures
  • Confocal Laser Scanning Microscopy
  • Confocal Microscopy
  • Gram-Positive Bacteria
  • Health Services
  • Infection
  • Infectious Diseases
  • Listeria Monocytogenes
  • Macrophages
  • Metabolism
  • Microbiology
  • Microscopy
  • Pathogenic Bacteria
  • Spreadsheet Software
  • Staphylococcus Aureus
  • Therapeutics
  • United States
  • Vaccines

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  • Strategic Security Studies