Genetic and Epigenetic Biomarker of Cutaneous Adverse Drug Reactions

Abstract

Goals. Complex: Discover epigenetic patterns responsible for ADRs through elucidation of epigenomes in relation to transcriptomes under different conditions. Simple. Identify a screenable biomarker associated with increased incidence of cutaneous ADR as to guide medication selection (personalized medicine). Trends. Genome-wide association studies (GWAS) for ADRS require smaller samples sizes than GWAS for common disease. Increasing associations with loci outside of the MHC region. Variants located in noncoding areas of the DMA. Increasing importance of understanding epigenetic influence.

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Document Details

Document Type
Technical Report
Publication Date
Apr 07, 2016
Accession Number
AD1036151

Entities

People

  • Thomas Beachkofsky

Organizations

  • 59th Medical Wing

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Biological Markers
  • Dermatology
  • Diagnostic Techniques (Medicine)
  • Epigenome
  • Genetic Phenomena
  • Personalized Medicine
  • Universities

Fields of Study

  • Biology

Readers

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  • Molecular Genetics
  • Oncology

Technology Areas

  • Biotechnology