GCMS/MS Analyses of Biological Samples in Support of Evaluation of Toxicity Associated with Intravenous Exposure to VX Stereoisomers in Guinea Pigs

Abstract

This report documents the results of the gas chromatography tandem mass spectrometry analyses of blood, tissues, and organs (heart, lung, liver, kidney, and brain) that were obtained from guinea pigs intravenously exposed to various concentrations of O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate (VX) stereoisomers. The amount of O-ethyl methylphosphonofluoridate (VX-G) present in these biological samples was quantified using chemical ionization mass spectrometry with isotope dilution.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2017
Accession Number
AD1036276

Entities

People

  • Jeffrey M. Mcguire
  • Linnzi K. Wright
  • Michael W. Busch
  • Robert L. Kristovich

Organizations

  • Edgewood Chemical Biological Center

Tags

Communities of Interest

  • Counter WMD

DTIC Thesaurus Topics

  • Animals
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemistry
  • Chromatography
  • Department Of Homeland Security
  • Gas Chromatography
  • Mass Spectrometry
  • Nerve Agents
  • Range Finding
  • Rodents
  • Spectrometry
  • Spectroscopy
  • Stereoisomers
  • Test And Evaluation
  • Toxicity
  • Veins

Fields of Study

  • Chemistry

Readers

  • Aerosol Science/Aerosol Physics
  • Immunology
  • Neurotoxicology