CS Riot Control Agent Exposure in US Army Mask Confidence Training: Association Between Exposure to O-Chlorobenzylidene Malononitrile (CS) and Urinary Metabolite 2-Chlorophippuric Acid
Abstract
This study was conducted among US Army trainees at Fort Sam Houston, Texas to evaluate the association between exposure to 2-chlorobenzylidene malononitrile (CS riot control agent) and metabolite 2-chlorohippuric acid (CHA) measured in urine of test subjects (n=87) after completion of the Mask Confidence Training chamber exercise. This is the first study to apply personal monitoring and the CDCs CLIA approved CS Metabolites method (Code ERB-253) for sensitive analysis of CHA to explore the association between exposure and metabolite in a prospective, observational cohort. Exposure assessment was conducted using OSHA modified P and CAM 304. GC/ECD was used to quantify CS exposure concentrations. Solid phase extraction and HPLC/MS was used to quantify CHA metabolite in urine at pre-exposure, 2, 8, 24, and 30-hour post vii exposure time intervals. Urine samples were creatinine corrected to reduce variation in subject Glomerular filtration rates.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 20, 2016
- Accession Number
- AD1036445
Entities
People
- Maccon A. Buchanan
Organizations
- Uniformed Services University of the Health Sciences