Evaluation of a Physiologically Based Pharmacokinetic (PBPK) Model Used to Develop Health Protective Levels for Trichloroethylene

Abstract

Trichloroethylene (TCE) was commonly used as a solvent by the Department of Defense (DoD), as well at private sector facilities. Releases to the environment from its past use make TCE one of the most common contaminants encountered at hazardous waste sites. The Air Force Research Laboratory previously worked with the U.S. Environmental Protection Agency (EPA) to develop a harmonized physiologically-based pharmacokinetic (PBPK) model for TCE; the model was updated by EPA for their use in their toxicological review. An evaluation of the updated PBPK model will provide insight into the uncertainty associated with its use by EPA.

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Document Details

Document Type
Technical Report
Publication Date
Feb 28, 2017
Accession Number
AD1036558

Entities

People

  • David R. Mattie
  • Jeffery M. Gearhart
  • Tammie R. Covington
  • Teresa R Sterner

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Air Force Research Laboratories
  • Alkenes
  • Blood
  • Civil Engineering
  • Computational Biology
  • Department Of Defense
  • Digestive System Processes
  • Engineers
  • Environmental Protection
  • Hazardous Waste
  • Hazardous Waste Sites
  • Health
  • Medical Personnel
  • Military Research
  • Public Health
  • Veins

Fields of Study

  • Environmental science

Readers

  • Computational Modeling and Simulation
  • Groundwater Contamination Remediation.
  • Toxicology/Environmental Toxicology