Regulation of Polysaccharide- and Protein- Specific Antibody Responses to Intact Extracellular Bacteria
Abstract
Many studies have been published detailing the mechanisms of antibody production in response to bacterial polysaccharides (PS) and proteins, either in soluble, isolated form and/or as conjugate vaccines composed of an immunogenic carrier protein covalently linked to PS. However, much less is knownregarding antibody responses to PS and protein expressed naturally by intact extracellular bacteria. We describe two major projects in mice that investigated the mechanism of PS- and/or protein-specific anti-IgG responses to intact, heat-killed Gram-positive and/or Gram-negative bacteria, in comparison to PS- and/or protein-specific IgG responses elicited by isolated PS or protein, and/or conjugate vaccine.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 11, 2016
- Accession Number
- AD1036792
Entities
People
- Swagata Kar
Organizations
- Uniformed Services University of the Health Sciences