Hazard Assessment of High-Nitrogen Explosive Compounds: A Novel In Vitro Multi-Cellular Approach

Abstract

The energetic properties of high-nitrogen (high-N) content materials have increased the interest towards their development for use in insensitive munitions. However, the use of such compounds in the production of explosives is known to lead to an increased risk of adverse health effects in munition factory workers and the general population through various occupational and environmental exposure pathways. While chemical hazard assessment with live animals has many advantages, the high cost of in vivo testing, in terms of resource consumption, animal usage, and time, only allows for the testing of a limited number of compounds.

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Document Details

Document Type
Technical Report
Publication Date
Mar 21, 2016
Accession Number
AD1036855

Entities

People

  • Tony Maurais

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Biomedical And Dental Materials
  • Cell Physiological Processes
  • Cells
  • Chemical Analysis
  • Chemical Synthesis
  • Chemistry
  • Fish
  • Insensitive Explosives
  • Organic Chemistry
  • Polymer Chemistry
  • Polymeric Films
  • Proteins
  • Proteomics

Readers

  • Aviation Safety Risk Assessment.
  • Munitions and Ordnance Engineering
  • Quantum Chemistry