Antibiotic Resistance In Neisseria Gonorrhoeae: Impact Of Ceftriaxone Resistance On Microbial Fitness And Potential Of Resistance Determinants To Spread During Mixed Infection

Abstract

Approximately 106 million cases of gonorrhea occur worldwide each year, and antibiotic treatment is critical for control. However, the rapid evolution of drug resistance in Neisseria gonorrhoeae (Gc) threatens this strategy. Extended-spectrum cephalosporins (ESC), including ceftriaxone (Cro), are the last remaining monotherapy for gonorrhea. Increasing resistance of Gc to the ESCs has amplified the threat of untreatable gonorrhea. Cro resistance in Gc is conferred primarily by mosaic penA alleles that encode multiple amino acid substitutions within penicillin-binding protein 2 (PBP 2).

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Document Details

Document Type
Technical Report
Publication Date
Mar 07, 2016
Accession Number
AD1036927

Entities

People

  • Leah R. Vincent

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Bacterial Infections
  • Bacteriology
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Health Services
  • Medical Personnel
  • Microbiology
  • Microbiomes

Fields of Study

  • Biology

Readers

  • Aerospace Engineering
  • Infectious Disease/Epidemiology
  • Oncology

Technology Areas

  • Biotechnology