Reappraisal of "Benign" Lymphoepithelial Sialadenitis for Evidence of Extranodal Marginal Zone B-Cell Lymphoma
Abstract
Introduction. Since the earliest descriptions of lymphoid lesions in the salivary glands, there has been debate regarding the differentiation of reactive and neoplastic lesions, benign and malignant processes and the significance of molecular features such as light chain restriction or immunoglobulin (Ig) heavy chain gene rearrangement. Lymphoepithelial sialadenitis (LESA), formerly known as benign lymphoepithelial lesion (BLEL), is a reactive process characterized by the infiltration of lymphocytes into the salivary gland. Extranodal marginal zone B-cell lymphoma (EMZBCL) is a malignant lymphoproliferative disease thought to arise in mucosa-associated lymphoid tissue (MALT) acquired in the development of LESA. Differentiating between these lesions is challenging due to their morphologic similarities, although modern molecular and immunohistochemical (IHC) staining techniques may provide mechanisms to reliably distinguish them. Objective. The aim of this study was to evaluate archival historic cases of BLEL for morphologic features, immunohistochemical profile, evidence of monoclonality and the presence of cytogenetic alterations previously identified in EMZBCL. Methods. Twenty cases of BLEL involving major salivary glands (18 parotid and 2 submandibular) were retrieved from the Joint Pathology Center Tissue Repository and evaluated for morphologic, immunophenotypic, molecular and cytogenetic abnormalities associated with EMZBCL.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 28, 2016
- Accession Number
- AD1036943
Entities
People
- Rachel L. Werner
Organizations
- Uniformed Services University of the Health Sciences