A Proposed Mechanism for Hypobaria Induced Neuronal Injury: A Swine Model

Abstract

Non-hypoxic hypobaric exposure in Air Force U-2 pilots and hypobaric chamber personnel is associated with increased brain white matter hyperintensities (WMH) and decrements in neurocognitive processing. The mechanism for this is unknown. We hypothesized that if injury is due to diffuse axonal degradation, this would manifest as changes in unrestricted water diffusion and be demonstrable through diffusion magnetic resonance imaging (MRI), utilizing advanced techniques such as multi-b-value diffusion (Q-space) and kurtosis anisotropy. We developed a swine model to test this theory.

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Document Details

Document Type
Technical Report
Publication Date
Apr 22, 2017
Accession Number
AD1037162

Entities

People

  • John H. Sladky
  • Paul Sherman
  • Philippine D. Peralta
  • Stephen A McGuire

Organizations

  • 59th Medical Wing

Tags

DTIC Thesaurus Topics

  • Air Force
  • Anisotropy
  • Chambers
  • Degradation
  • Diffusion
  • Hypobaric Chambers
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Medical Personnel
  • Military Personnel
  • Neurology
  • Resonance

Readers

  • Aerosol Science/Aerosol Physics
  • Auditory Neuroscience/Auditory Physiology.
  • Electromagnetic Wave Scattering and Antenna Radiation Engineering

Technology Areas

  • Space