The Relationship Between Fatty Liver Disease and Periodontal Disease
Abstract
Periodontitis is a highly prevalent and destructive chronic disease. Numerous studies support an association between periodontal disease and other systemic diseases (diabetes, cardiovascular disease, chronic kidney disease, adverse pregnancy outcome, etc.). Non-alcoholic fatty liver disease is a chronic inflammatory disease that is characterized by accumulation of triglycerides and fat in the liver which may lead to fibrosis and even cirrhosis. The mechanism of this destruction is due to activation of inflammatory cells and up regulation of cytokines, much like the chronic inflammatory destruction seen in periodontal disease. The association between the two diseases has never been investigated. A reasonable mechanism in which periodontal disease may play a role in the destruction seen in NAFLD is the remote site infection of periodontal disease. Chewing and oral hygiene measures lead to systemic release of bacterial byproducts and subsequent systemic inflammatory response which may subsequently lead to the changes seen in the liver. Objective: The purpose of this cross-sectional study is to investigate the relationship between periodontal disease and NAFLD.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 22, 2017
- Accession Number
- AD1037219
Entities
People
- Angelo Paredes
- Brian Mealey
- Chol Chong
- John Magulick
- Sarah M. Ringdahl
Organizations
- 59th Medical Wing