Advancements in DNA Vaccine Vectors, Non-Mechanical Delivery Methods and Molecular Adjuvants to Increase Immunogenicity
Abstract
A major advantage of DNA vaccination is the ability to induce both humoral and cellular immune responses. DNA vaccines are currently used in veterinary medicine, but have not achieved widespread acceptance for use in humans due to their low immunogenicity in early clinical studies. However, recent clinical data have re-established the value of DNA vaccines, particularly in priming high-level antigen-specific antibody responses. Several approaches have been investigated for improving DNA vaccine efficacy, including advancements in DNA vaccine vector design, the inclusion of genetically engineered cytokine adjuvants, and novel non- mechanical delivery methods. These strategies
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 15, 2017
- Accession Number
- AD1037367
Entities
People
- Connie S Schmaljohn
- James A. Williams
- John J Suschak
Organizations
- United States Army Medical Research Institute of Infectious Diseases