Host Gene Expression Analysis in Sri Lankan Melioidosis Patients

Abstract

Melioidosis is a life threatening infectious disease caused by the gram-negative bacillus Burkholderia pseudomallei predominantly found in southeast Asia and northern Australia. Studying the host transcription profiles in response to infection is crucial for understanding disease pathogenesis and correlates of disease severity, which may help improve therapeutic intervention and survival. The aim of this study was to analyze gene expression levels of human host factors in melioidosis patients and establish useful correlation with disease biomarkers, compared to healthy individuals and patients with sepsis caused by other pathogens.

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Document Details

Document Type
Technical Report
Publication Date
Jun 19, 2017
Accession Number
AD1037368

Entities

People

  • Aruna D De Silva
  • Enoka M Corea
  • Harindra D. Sathkumara
  • Mohan Natesan
  • Nimanthi Jayathilaka
  • Shivankari Krishnananthasivam

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Adaptive Immunity
  • Allergy And Immunology
  • Bacteria
  • Blood
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Disease Attributes
  • Gene Expression
  • Health Services
  • Infectious Diseases
  • Liver Diseases
  • Lymphocytes
  • Medical Personnel
  • Polymerase Chain Reaction
  • Proteins
  • Sepsis

Fields of Study

  • Medicine

Readers

  • Microbial Pathology
  • Trauma or Military Medicine
  • Virology (or Medical Virology).