Ovarian Sertoli-Leydig Cell Tumor with Elevated Inhibin B As a Cause of Secondary Amenorrhea in Adolescents with Germline DICER1 Mutation

Abstract

Background: Although uncommon in children, ovarian tumors can retain endocrine function that disrupts normal feed back mechanisms leading to a menorrhea. Inheritance of germline DICER1 mutations can lead to increased risk for development of ovarian Sertoli-Leydig cell tumors (SLCT). Case: We report the case of an adolescent female who developed secondary amenorrhea due to elevated inhibin B levels from an ovarian SLCT. Summary and Conclusions: Ovarian tumors should be included in the differential diagnosis for pediatric patients presenting with menstrual irregularities. Early evaluation of the hypothalamic pituitary- ovarian axis is appropriate to include screening of inhibin levels if an ovarian mass is identified. Our case also emphasizes the need for testing of DICER! mutations in pediatric patients with ovarian SLCTs.

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Document Details

Document Type
Technical Report
Publication Date
Apr 06, 2017
Accession Number
AD1037427

Entities

People

  • Amy M. Luke
  • Andrea Snitchler
  • John W. Moroney
  • Susan L. Whiteway

Organizations

  • 59th Medical Wing

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Adolescents
  • Biomedical Research
  • Department Of Defense
  • Diseases And Disorders
  • Electronic Mail
  • Endocrine Glands
  • Health Services
  • Hormones
  • Intellectual Property
  • Law
  • Materials
  • Medical Personnel
  • Neoplasms
  • Pain
  • Sarcoma
  • Sex Glands

Fields of Study

  • Medicine

Readers

  • Military/Explosive Ordnance Disposal (EOD) Technology
  • Molecular Biology and Genetics
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.