Impact of Juvenile Cannabinoid Receptor Targeting on Adult Restrictive-Repetitive Behaviors and Cytokine Expression

Abstract

Restrictive-repetitive behavior are a core autism symptom that can be modeled in mice for behavioral pharmacology studies.. Marble burying is an index of repetitive behavior that is sensitive to sedatives. In prior studies WIN55,212-2 (0.1 mg/kg), a cannabinoid receptor (CB1 and CB2) agonist, attenuated burying. Yet marble burying captures only "lower order" repetition, paralleling stereotopies like repetitive movements or manipulation of objects. To examine higher order restrictive "perseverative" behaviors such as insistence on sameness (narrow interests), cognitive flexibility or "reversal learning" tests provide more insight.

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Document Details

Document Type
Technical Report
Publication Date
Nov 11, 2017
Accession Number
AD1037882

Entities

People

  • C. Amaya
  • L. Ferreira
  • N. A. Witt
  • S. T. Schultz
  • Sandra Valtier

Organizations

  • 59th Medical Wing

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Cytokines
  • Hypnotics And Sedatives
  • Learning
  • Neurosciences
  • Pharmacology
  • Resilience
  • Targeting

Fields of Study

  • Biology
  • Psychology

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Joint Military Operations and Doctrine.