Concentrations of Serum Inflammatory Markers after Hypobaric Exposure in Aircrew Trainees

Abstract

Background: Recurrent non-hypoxic hypobaric exposure in Air Force U-2 pilots is associated with acquired decrements in neurocognitive performance with parallel diffuse axonal injury demonstrated on magnetic resonance imaging (MRI). The pathophysiology of this brain injury is not well understood but may be related to quantitative changes in inflammatory serum markers. The aim of this study is to assess whether protein and cytokine concentrations change that inflammatory markers, which elevate in decompression sickness, traumatic brain injury (TBI), and various neurological conditions associated with decreased neurocognitive performance, would change in response to hypobaric exposure.

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Document Details

Document Type
Technical Report
Publication Date
Aug 27, 2017
Accession Number
AD1038311

Entities

People

  • John H. Sladky
  • Kelsey A Cacic
  • Paul Sherman
  • Steven Mcguire

Organizations

  • 59th Medical Wing

Tags

DTIC Thesaurus Topics

  • Air Force
  • Brain Injuries
  • Decompression Sickness
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Resonance

Fields of Study

  • Medicine

Readers

  • Aviation Science / Aeronautics.
  • Immunology
  • Neuroscience