One Generation Reproductive Toxicity Test in Japanese quail (Coturnix japonica) Exposed Orally to 3-nitro-1,2,4-triazol-5-one (NTO), February-August 2015
Abstract
Repeated oral exposures to 500 and 1000 mg/kg-day-NTO induced neuromuscular signs and compound-related pre-term mortality in male and female Japanese quail. Birds exhibited convulsions, circling on the floor of the cage, backward arching of the neck (opisthotonos), and alternated between prostrate inactivity and ataxic wing activity. In conjunction with neuromuscular signs, decreased body mass gain occurred in birds as early as one week into exposure. Ultimately, all of the 1000 mg/kg-day birds and all but one of the 500 mg/kg-day birds met euthanasia criteria and were sacrificed. Histopathology could not determine the cause of death in F0 generation birds from the 500 and 1000 mg/kg-day groups.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 14, 2017
- Accession Number
- AD1038395
Entities
People
- Allison M. Jackovitz
- Desmond I Bannon
- Keith A. Koistinen
- Mark S. Johnson
- Michael Jr J. Quinn
Organizations
- United States Army Center for Health Promotion and Preventive Medicine