Closed Loop Control of Oxygen Delivery and Oxygen Generation
Abstract
Maintenance of adequate oxygenation and prevention of hypoxemia are the primary goals for the battlefield casualty, but in military operations, oxygen is a limited resource to be conserved. A portable oxygen concentrator has the advantage of operating solely from electrical power and therefore is a never-exhausting supply of oxygen. Our previous bench work demonstrated that the pulsed dose setting of the concentrator can be used in concert with the ventilator to maximize oxygen delivery. We evaluated this ventilator/ concentrator system with closed loop control of oxygen output in a porcine model. The Zoll 731 portable ventilator and Sequal Saros portable oxygen concentrator were used for this study and were connected via a USB cable to allow communication. The ventilator was modified to allow closed loop control of oxygen based on the oxygen saturation (SpO2) via the integral pulse oximetry sensor. Twelve pigs were used for the evaluation. The animals were placed on a ventilator on 100 fraction of inspired oxygen (FIO2) and lung injury was induced by warmed saline lavage via the endotracheal tube until partial pressure of oxygen (PaO2)/FIO2 decreased to < 100. The pigs were then placed on the ventilator/concentrator system and allowed to adjust the oxygen autonomously to determine if the target SpO2 could be maintained.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2017
- Accession Number
- AD1038554
Entities
People
- Dario Rodriquez
- Jay Johannigman
- Richard D Branson
- Thomas C Blakeman
Organizations
- University of Cincinnati