Intravesical NGF Antisense Therapy Using Lipid Nanoparticle for Interstitial Cystitis

Abstract

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating disorder characterized by persistent pelvic pain associated with bladder symptoms including urinary frequency and urgency. Previous studies have indicated that overexpression of nerve growth factor (NGF) isan important factor in the symptom development of IC/BPS. This project evaluates the potential of an anti-NGF bladder drug delivery system as a potential investigational drug product indicated for IC/BPS. The investigational drug product is a proprietary liposome NGF-antisense formulation given the development name of LP-11. The project aims included research, manufacture, and nonclinical testing of LP-11. The long-term objective of the research program is to establish new local anti-NGF therapy for the treatment of IC/BPS.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2016
Accession Number
AD1039020

Entities

People

  • David Chancellor
  • Michael B Chancellor
  • Michele Gruber
  • Naoki Yoshimura

Tags

DTIC Thesaurus Topics

  • Antisense Therapy
  • Diseases And Disorders
  • Drug Therapy
  • Frequency
  • Growth Factors
  • Materials
  • Medical Personnel
  • Mucous Membrane
  • Nanoparticles
  • Neural Pathways
  • Pain
  • Particle Size
  • Statistical Analysis
  • Synthetic Membranes
  • Therapy
  • Urinary Tract
  • Urinary Tract Physiological Phenomena

Fields of Study

  • Medicine

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech