Prazosin Augmentation of Outpatient Treatment of Alcohol Use Disorders in Active Duty Soldiers with and without PTSD

Abstract

This project is a 12-week randomized controlled trial (RCT) of prazosin for AUD in 200 OIF/OEF soldiers both withand without comorbid PTSD enrolled in the Alcohol and Substance Abuse Program (ASAP) at Madigan HealthCare System/Joint Base Lewis McChord. The aims of this trial are 1) to determine prazosins efficacy for AUD inOIF/OEF soldiers participating in outpatient AUD treatment and 2) to determine if the presence of PTSD affectsprazosin efficacy for AUD. In the first year of the study, the protocol was extensively review and recently approvedby the VA Puget Sound IRB. This approval was necessary before the Madigan IRB would review the protocol.Madigan IRB has now accepted the studys application and we anticipate their approval by end of November 2013;this would allow an early December 2013 start of participant randomization.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2014
Accession Number
AD1039060

Entities

People

  • Murray A. Raskind

Organizations

  • Seattle Institute for Biomedical and Clinical Research

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Active Duty
  • Afghanistan Conflict
  • Antidepressants
  • Brain Injuries
  • Cardiovascular Physiological Phenomena
  • Cognition
  • Combat Injuries
  • Department Of Veterans Affairs
  • Diseases And Disorders
  • Health Care
  • Health Services
  • Institutional Review Board
  • Medical Personnel
  • Psychiatry
  • Puget Sound

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Mental Health of Military Veterans with Posttraumatic Stress Disorder (PTSD): Risk Factors, Prevalence, Symptoms, and Treatment.