Novel Therapy for Bone Regeneration in Large Segmental Defects
Abstract
The purpose of this study is to test the efficacy of thrombopoietin (TPO) to heal a segmental bone defect (SBD) in a large animal model, the minipig. The scope of the research comprises the following specific aims (i) to determine the union rate of tibial midshaft defects in minipigs treated with BMP-2, TPO, or saline control; and (ii) to evaluate the safety and side effects of treating tibial midshaft defects in minipigs treated with BMP-2, TPO, or saline control. In the previous research periods we completed surgeries and collection of tissue/data from 27 minipigs which had surgeries with IM nail fixation and 12 minipigs which had surgeries with compression plate fixation. Perhaps the two most significant findings during this period are that we discovered that fixation type (IM nail vs. compression plates) impacts the size requirement for a critical size defect, and that even with a large segmental defect, that is not of critical size, TPO is able to more rapidly allow for bone healing than observed in saline treated controls. We believe with creating a large defect but with using compression plate fixation we can even further improve TPOs efficacy, which along with finalizing data collection from the previous pig surgeries, will be the main goals in our 1 year no cost extension period (Year 4).
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2016
- Accession Number
- AD1039367
Entities
People
- Melissa A. Kacena
- Tien-min Chu
- Todd O McKinley
Organizations
- Indiana University