CDCA7L and Mechanisms of Increased Male Bias in Glioma

Abstract

We are proposing to study CDCA7L in an NF1 mutant model of astrocytoma and glioblastoma and in neurotransmitter levels in NF1 mutant brains, comparing males and females. The results of his work can be used to develop additional hypotheses on whether a "yin-yang" relationship exists in males and females between risk for brain cancer and risk for depression, or other earning and social dysfunctions. Developing new treatments for gliomas and learning/social dysfunction through a better understanding of the basic biology will benefit both male and female NF1 patients in the long term.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2017
Accession Number
AD1039647

Entities

People

  • Karlyne Reilly

Organizations

  • Geneva Foundation

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Brain
  • Catecholamines
  • Cell Physiological Processes
  • Cells
  • Depression
  • Diseases And Disorders
  • Genetic Variation
  • Genetics
  • Histology
  • Medical Personnel
  • Mutations
  • Neoplasms
  • Nervous System
  • Neurons
  • Phenotypes
  • Transcription Factors

Readers

  • Gender and Food Studies
  • Molecular and Cellular Biology
  • Oncology