Genetic Alterations in Prostate Cancers among African American Men and Comparisons with Cancers from European and Asian Patients
Abstract
A large and systematic evaluation of somatically acquired changes in the tumors of African American man is needed to identify race-specific signatures that may be associated with increased aggressive and poor outcome of prostate cancer (PCa) in this under-studied population. We have analyzed DNA copy number alterations (CNAs) in a subset of the tumors from African Americans with PCa and compared them to those in European American and Chinese PCa. Our data reveal that the most frequent CNAs include hemizygous deletions on chromosomal 8p and 13q represented by BNIP3L and RB1, respectively. To our surprise, no subjects in this subset of African American patients harbored the deletion between the 3 of TMPRSS2 and 3 ERG (T_E) that creates the fusion of these two genes. Preliminary result analysis suggests that the tumor genome of African American PCa may harbor a distinct CNA landscape, though analyzing a large number of tumors from additional patients is warranted to confirm our findings. In addition, we have developed a multiplex ligation-dependent probe amplification (MLPA)-based method and a probe mix panel for identifying PTEN deletions and MYC amplifications that have been shown to be associated with lethal PCa. Additional experiments are needed to demonstrate the utility of this probemix for the identification of patients with aggressive PCa in African Americans.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2016
- Accession Number
- AD1039661
Entities
People
- Xu Jianfeng
Organizations
- NorthShore University HealthSystem