Pupillometry and Saccades as Objective mTBI Biomark

Abstract

The objective of the study is to validate pupillary light reflex (PLR), saccadic and convergence eye movements as objective biomarkers for the identification of Warfighters with acute mild traumatic brain injury (mTBI) using commercial-off-the-shelf (COTS) instruments: infrared pupillometers, King-Devick (KD) test and near point of convergence (NPC) rule,respectively. Hundred mTBI and 100 age-matched non-TBI (controls) military personnel were recruited from the patient population at Womack Army Medical Center (WAMC). This study was designed to determine within each group the effectiveness of these tests, individually and/orin combination, to correctly identify mTBI in agreement with the mTBI diagnosis made by the WAMC Department of Brain Injury Medicine. Results showed that three of the eight PLR parameters are statistically different between the groups: average constriction velocity, average dilation velocity, and 75% dilation recovery time. In addition, the KD test, NPCrule, and the CISS survey showed sensitivity in identifying military personnel with mTBI.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2017
Accession Number
AD1039692

Entities

People

  • José E. Capó-aponte

Organizations

  • Geneva Foundation

Tags

DTIC Thesaurus Topics

  • Anxiety Disorders
  • Brain
  • Brain Injuries
  • Data Analysis
  • Databases
  • Diseases And Disorders
  • Eye Movements
  • Health Services
  • Identification
  • Information Science
  • Medical Personnel
  • Military Medicine
  • Military Personnel
  • Regression Analysis
  • Statistical Analysis
  • Surveys
  • Traumatic Stress Disorder

Readers

  • Mental Health of Military Veterans with Posttraumatic Stress Disorder (PTSD): Risk Factors, Prevalence, Symptoms, and Treatment.
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.
  • Vision Science/Vision Psychology/Cognitive Neuroscience.