Investigation of Intravenous Hydroxocobalamin Compared to Hextend for Resuscitation in a Swine Model of Uncontrolled Hemorrhagic Shock: A Preliminary Report

Abstract

Previously we reported that intravenous (IV) hydroxocobalamin is as effective as IV Hextend in improving systolic blood pressure (SBP) in a controlled hemorrhagic shock model. We aimed to compare IV hydroxocobalamin (HOC) to Hextend using an uncontrolled hemorrhage model. Non-compressible wounds are difficult to treat. An ideal resuscitative fluid would be a small volume, portable drug that improves blood pressure and survival.

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Document Details

Document Type
Technical Report
Publication Date
Aug 27, 2017
Accession Number
AD1040799

Entities

People

  • D. Hyams
  • Joseph K Maddry
  • K. Canellis
  • M. Castaneda
  • N. Garrett
  • S. Boudreau
  • V. S. Bebarta

Organizations

  • 59th Medical Wing

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Arteries
  • Blood
  • Cardiovascular Physiological Phenomena
  • Department Of Defense
  • Emergency Medicine
  • Emergency Treatment
  • Hemorrhage
  • Hemorrhagic Shock
  • Memory Devices
  • Military Medicine
  • Pathologic Processes
  • Resuscitation
  • Symptoms And General Pathology

Readers

  • Cardiovascular Physiology
  • Trauma Surgery or Emergency Medicine.