Saline Alone vs Saline plus Mannitol Hydration for the Prevention of Acute Cisplatin Nephrotoxicity: A Randomized Trial

Abstract

Cisplatin is widely used as an effective chemotherapy in diverse neoplasms and is associated with renal toxicity. Several studies suggest that pre-hydration plus mannitol prior to chemotherapy with cisplatin prevents nephrotoxicity. The aim of this study is to determine the acute effects of hydration plus mannitol on renal function in patients receiving cisplatin.

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Document Details

Document Type
Technical Report
Publication Date
Oct 15, 2017
Accession Number
AD1040828

Entities

People

  • Doug Nelson
  • Frederick Flynt
  • James K. Aden
  • Melissa King
  • Naomi Hullinger
  • Sandra Terrazzino
  • Tiffany Byrd
  • Wilfred Dela Cruz

Organizations

  • 59th Medical Wing

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Cancer
  • Chemotherapy
  • Creatinine
  • Department Of Defense
  • Hydration
  • Lung Cancer
  • Mannitol
  • Military Medicine
  • Neoplasms
  • Saline Solution
  • Toxicity
  • United States

Readers

  • Military History
  • Molecular and Cellular Biochemistry
  • Toxicology/Environmental Toxicology