Antifungal Resistance Patterns in Molds Isolated from Wounds of Combat Related Trauma Patients
Abstract
Background: An outbreak of trauma-related invasive fungal infections (IFI) occurred in US service members injured in Afghanistan. Empiric treatment included voriconazole (VORl) and amphotericin (AMB) and aggressive surgical debridement. Antifungal susceptibilities (AS) and relation to outcoID Week, San Diego, CA, Oct 5 2017mes are yet to be described. Methods: Between 2009-2013, military trauma patients with initial unique and serial (>3 days after initial isolation) molds isolated from wounds and admitted to Brooke Anny Medical Center as part of the Trauma Infectious Disease Outcomes Study were assessed. The AS to AMB, VORI, posaconazole (POSA), isavuconazole (ISA), itraconazole, and caspofungin were determined by broth microdilution with CLSI breakpoint interpretations for Aspergillus spp. and mucormycetes (MM). Results: Included are 18 patients with 28 initial mold isolates with 72% of lFI diagnosed via histopathology. All patients were male with a median of 8 operations. There was a median of 11 days post-injury to mold culture.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 05, 2017
- Accession Number
- AD1040938
Entities
People
- Aaron Farmer
- Anuradha Ganesan
- Clinton K. Murray
- Dana M. Blyth
- David R. Tribble
- Julie Rizzo
- Katrin Mende
- Miriam L. Beckius
- Nicholas Keaton
Organizations
- 59th Medical Wing