Study the Effect of KSL-W on Inflammatory Response of Engineered Human Oral Mucosa Following Candida albicans Infection
Abstract
Candida species are the most common opportunistic fungal pathogens in humans, with C.albicans being the most prevalent pathogen in mucosal and systemic fungal infections (Pfaller etal., 2002; Trick et al., 2002). The C. albicans fungus causes both systemic and local disease. Fungal invasion of the superficial oral epithelial cells is a characteristic of oropharyngeal candidiasis (Farah et al., 2000; Eversole et al., 1997; Drago et al., 2000). C. albicans invasion of host cells, such as oral epithelial cells, is necessary for the organism to damage these cell types invitro (Filler et al., 1995; Park et al., 2005). Host cell invasion and damage are likely critical virulence attributes of C. albicans (Park et al., 2005; Phan et al., 2000).
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2010
- Accession Number
- AD1041412
Entities
People
- Mahmoud Rouabhia