Vision Integrating Strategies in Ophthalmology and Neurochemistry (VISION)

Abstract

The overall goal of the VISION project is to discover neuroprotective strategies in three separate mouse models of injury to the visual axis, in order to identify potential candidates for the treatment of combat eye injuries and preserve vision in our injured warfighters. We have established three different mouse models of ocular injury with different injury- initiating mechanisms (i.e. optic nerve crush, retinal ischemia/reperfusion, and chronic ocular hypertension). We have developed techniques to quantify damage to the retina, optic nerve, and visual axis in the brain (i.e. superior colliculus) that are damaged in these three models.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2016
Accession Number
AD1041425

Entities

People

  • Abbot Clark
  • Thomas Yorio

Organizations

  • University of North Texas

Tags

DTIC Thesaurus Topics

  • Brain
  • Cell Physiological Processes
  • Central Nervous System
  • Chemistry
  • Diseases And Disorders
  • Estrogens
  • Eye Diseases
  • Eye Injuries
  • Gene Therapy
  • Hypertension
  • Medical Personnel
  • Nervous System
  • Ophthalmology
  • Optic Nerve
  • Proteins
  • Transcription Factors
  • Vascular Diseases

Readers

  • Neurotrauma and Rehabilitation Medicine.
  • Vision Science/Vision Psychology/Cognitive Neuroscience.