Human Cell Line Activation Test of the Novel Energetics Methyl Trinitropryrazol (MTNP) and 1,3-Dimethylhexahydropyrimidine (DHP)

Abstract

The energetic and toxicological properties of methyl trinitropyrazol (MTNP) and 1,3-dimethylhexahydropyrimidine (DHP) are being determined to support an evaluation of these compounds as replacements for energetics in current use, such as such as hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and trinitrotoluene (TNT). This study assessed the skin sensitization potential of MTNP and DHP through the human cell line activation test (h-CLAT), an in vitro approach to assess dendritic cell activation by chemicals, a critical step in the induction of a skin allergy. MTNP induced a positive reaction in the assay, while DHP did not.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2017
Accession Number
AD1042152

Entities

People

  • Emily N. Reinke

Organizations

  • United States Army Center for Health Promotion and Preventive Medicine

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Albumins
  • Anti-Bacterial Agents
  • Cell Line
  • Cells
  • Data Analysis
  • Department Of Defense
  • Engineering
  • Environment
  • Health
  • Instructions
  • Materials
  • Military Research
  • Public Health
  • Range Finding
  • Standards
  • Tissue Culture

Fields of Study

  • Chemistry

Readers

  • Agricultural Chemistry/Soil Science
  • Molecular and Cellular Biology