Human Cell Line Activation Test of the Novel Energetics 2,6-pyrazinediamine 3,5-dinitro 1 -oxide (LLM-105) and 2,4,6-trinitro-3-bromoanisole (TNBA)

Abstract

The energetic and toxicological properties of 2,6-pyrazinediamine 3,5-dinitro-1 -oxide (LLM-105) and 2,4,6-trinitro-3-bromoanisole (TNBA) are being determined to support an evaluation of LLM-105 and TNBA as replacements for energetics in current use, such as such as hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and trinitrotoluene (TNT). This study assessed the skin sensitization potential of LLM-105 and TNBA through the human cell line activation test (h-CLAT), an in vitro approach to assess dendritic cell activation by chemicals, a critical step in the induction of a skin allergy. Both compounds induced a positive response in the assay.

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Document Details

Document Type
Technical Report
Publication Date
Nov 06, 2017
Accession Number
AD1042154

Entities

People

  • Emily N. Reinke

Organizations

  • United States Army Center for Health Promotion and Preventive Medicine

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Albumins
  • Anti-Bacterial Agents
  • Cell Line
  • Cells
  • Data Analysis
  • Department Of Defense
  • Environment
  • Health
  • Instructions
  • Materials
  • Molecular Structure
  • Munitions
  • Public Health
  • Range Finding
  • Standards
  • Tissue Culture

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  • Agricultural Chemistry/Soil Science
  • Immunology