Non invasive Imaging based Detection and Mapping of Brain Oxidative Stress and its Correlation with Cognative Functions

Abstract

Brain stress level measurement (non-invasively) in quantitative term is very helpful to correlate with various neuropsychological outcome. Brain protective anti-oxidant called glutathione level is affected with aging process due to increased stress. This pilot project is the first human study to measure the brain glutathione level and also perform various neuropsychological test to investigate any possible correlation between glutathione (GSH) level and neuropsychological outcome. We have found that at the age of 40 onwards, there is a depletion of brain glutathione level and these subject population (above 40Y) face more difficult to perform certain neuropsychological tests, which is easily performed by young subject (below 35Y old).

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Document Details

Document Type
Technical Report
Publication Date
May 14, 2017
Accession Number
AD1042610

Entities

People

  • Pravat Mandal

Organizations

  • National Brain Research Centre

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Air Force
  • Air Force Facilities
  • Air Force Research Laboratories
  • Antioxidants
  • Department Of Defense
  • Detection
  • Hippocampus
  • Military Research
  • Neuroimaging
  • Oxidative Stress
  • Pilot Studies
  • Psychological Tests
  • Scientific Research
  • Steady State

Readers

  • Molecular and Cellular Biochemistry
  • Neuroscience
  • Psychometric Testing or Psychological Assessment.