Intra-Articular Lubricin Gene Therapy for Post-Traumatic Arthritis

Abstract

This project focuses on addressing cartilage lubricant failure in post-traumatic osteoarthritis (PTOA) via intra-articular lubricin/proteoglycan 4 (PRG4) gene therapy. Our findings thus far indicate that a single intra-articular injection of adeno-associated virus (AAV) bearing the PRG4 gene in a rabbit ACL transection (ACLT) model resulted intransgene expression until the end-point of the experiment at 8 weeks post-op, and that the injection was significantly chondroprotective, while injections of control virus (AAVGFP) were not. These data indicate that PRG4 gene therapy is a viable option for slowing the progression of PTOA, a finding that warrants progression to a large animal model.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2017
Accession Number
AD1042687

Entities

People

  • James A. Martin

Organizations

  • University of Iowa

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Arthritis
  • Biomedical Research
  • Cartilage
  • Confocal Microscopy
  • Data Analysis
  • Department Of Defense
  • Diseases And Disorders
  • Gene Therapy
  • Histology
  • Lubricants
  • Medical Personnel
  • Peptide Growth Factors
  • Statistical Analysis
  • Surgery
  • Technicians
  • Therapy
  • Tissues

Fields of Study

  • Biology

Readers

  • Educational Psychology
  • Neurotrauma and Rehabilitation Medicine.
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology