Androgen Receptor Splice Variants and Resistance to Taxane Chemotherapy

Abstract

During this reporting period, we have obtained approval for a no-cost extension of this award and change of research focus in the final year. This report will summarize the research activities and achievements up to date, organized based on the revised Statement of Work. In summary, we have 1) Identified two regions in the AR LBD that confer the microtubule-binding activity; 2) Further characterized the functional significance of the AR-microtubule interaction and provided compelling evidence to suggest that the microtubules play an important role in controlling the intracellular localization and activity of AR; 3) Provided a fundamental understanding of the constitutive nuclear localization and transcriptional activities of AR-V7 and ARv567es; and 4) Developed and validated a whole-blood assay for the detection of both AR-V7 and ARv567es.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2017
Accession Number
AD1042924

Entities

People

  • Haitao Zhang

Organizations

  • Tulane University of Louisiana

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Androgen Receptors
  • Androgens
  • Biomedical Research
  • Cells
  • Chemotherapy
  • Cytoplasm
  • Cytoskeleton
  • Department Of Defense
  • Detection
  • Medical Personnel
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Resistance
  • Sequence Analysis
  • Therapy

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Prostate Cancer Biology.
  • Technical Research and Report Writing.