The Roles of the Bone Marrow Microenvironment in Controlling Tumor Dormancy

Abstract

The purpose of this study is to identify the mechanisms whereby the bone marrow microenvironment is involved in the regulation of tumor dormancy. Aim1 will identify and explore how disseminated tumor cells (DTCs) stay dormant for longperiods of time. We postulate that DTCs drive the bone marrow niche into dormancy through the GAS6 pathway. Aim2 will determine how DTCs escape dormancy, consequently rendering them more susceptible to the chemotherapy. During this period, we found that a fast growing less differentiated osteoblast may contribute to growth of bone metastatic prostate cancer. In addition, we developed a new and creative in vitro cell culture system that allows us to evaluate the effects of osteoblastic activation on the growth of disseminated prostate cancer cells.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2017
Accession Number
AD1042929

Entities

People

  • Yusuke Shiozawa

Organizations

  • Wake Forest University

Tags

DTIC Thesaurus Topics

  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Health Services
  • Medical Personnel
  • Peptide Growth Factors

Readers

  • Data Mining and Knowledge Discovery.
  • Oncology (Cancer Research).