Acute and Two-Week Inhalation Toxicity Studies in Rats for Polyalphaolefin (PAO) Fluid

Abstract

Formal occupational exposure limits (OELs) for polyalphaolefin (PAO) fluids have not been proposed. Specific PAO fluids are used as aircraft hydraulic fluid components or heat sink coolants for aircraft service air and electronics. Studies compared toxicity of a PAO fluid in male and female Fischer 344 rats by acute inhalation (0, 100, 500 and 1000 mg/m3 aerosol for 6 hours) and two-week inhalation (0, 20, 100 and 300 mg/m3 aerosol for 6 hours/day, five days/week for two weeks). Neurobehavioral tests following the acute exposure showed that both sexes were passive after exposure to 1000 mg/m3 PAO, and to a lesser extent after 500 mg/m3 PAO. Body weight, food and water consumption were also affected, with recovery after 24 hours.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2017
Accession Number
AD1043038

Entities

People

  • Barry J. Marcel
  • Brian A. Wong
  • David R. Mattie
  • Karen L. Mumy
  • Matthew D. Wegner
  • R. A. James
  • Shawn M. Mcinturf
  • Teresa R Sterner

Organizations

  • Henry M. Jackson Foundation for the Advancement of Military Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Aerospace Medicine
  • Air Flow
  • Air Force
  • Air Force Operations
  • Aircrafts
  • Animal Structures
  • Biomedical Research
  • Blood
  • Blood Cells
  • Body Weight
  • Cells
  • Chemistry
  • Chi Square Test
  • Environmental Protection
  • Granulocytes
  • Heat Sinks
  • Hemorrhage
  • Human Behavior
  • Measurement
  • Medical Personnel
  • Motor Skills
  • Nose
  • Particle Size
  • Particles
  • Static Pressure
  • Statistical Analysis
  • Statistical Tests
  • Tissues
  • Wounds And Injuries

Fields of Study

  • Environmental science

Readers

  • Petroleum Engineering
  • Toxicology/Environmental Toxicology

Technology Areas

  • Microelectronics