Mathematical Model of HIF-1 alpha Pathway, Oxygen Transport and Hypoxia
Abstract
Episodes of hypoxia-like events experienced by F-22 pilots after training missions have raised questions about pilot exposures and diminished operational mission accomplishment. These episodes identified data gaps in the understanding of pilot exposures in high performance aircraft. We, therefore, need to understand how levels of low oxygen at lower than atmospheric pressure causes physiological hypoxia, and how this relates to alterations in cognition. Oxygen sensing pathways, particularly those involving the oxygen sensing cytosolic gene transcription factor HIF-1, are key to understanding these responses. A mathematical model was developed to integrate these experimental measurements and provide a description of hypoxia mechanisms and the organisms response.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2017
- Accession Number
- AD1043051
Entities
People
- C. E. Hack
- David R. Mattie
- Elaine A. Merrill
- Peter J. Robinson
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine