Use of Topical PC-NSAIDs to Treat Burn Injury and Pain

Abstract

Studies have shown that the rat dorsal skin and hind limb burn injury models of 2nd degree burns are appropriate for testing the analgesic and healing rate efficacy of test drugs. These models were used to test Ibuprofen (Ibu), Ibuprofen associated with phosphatidylcholine (Ibu-PC), Indomethacin (Indo), and Indo-PC. The experimental drug Indo-PC showed analgesic and anti-inflammatory efficacy over Indo alone or the Ibu drugs, notably when administered parenterally without notable side-effects. These studies support a rationale for continued development of parenteral Indo-PC for treatment of 2nd degree burn wounds.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2017
Accession Number
AD1043110

Entities

People

  • Lenard M. Lichtenberger

Organizations

  • University of Texas Health Science Center at Houston

Tags

DTIC Thesaurus Topics

  • Analgesia
  • Anti-Inflammatory Agents
  • Biomedical Research
  • Body Weight
  • Burns
  • Department Of Defense
  • Hair
  • Inflammation
  • Pain
  • Pain Management
  • Professional Development
  • Sensitivity
  • Side Effects
  • Skin
  • Standards
  • Technology Transfer
  • Tissues

Fields of Study

  • Biology

Readers

  • Cardiovascular Physiology
  • Geochemistry
  • Neurotrauma and Rehabilitation Medicine.