Toward a Molecular Understanding of Noise-Induced Hearing Loss

Abstract

The purpose of this project is to generate the cell type-specific molecular blueprint of changes in gene expression following different types of noise exposure and their treatments, in the inner ear. To this end, we have (a) Established the hair cell (HC) and supporting (SC) cell-specific translatome of adult mouse inner ears; (b) Established the molecular changes induced by PTS-resulting noise exposure in HC, SC and whole inner ears, 6 and 24 hours after noise exposure and began the TTS analysis; (c) We identified critical differences in the response of male and female mice to noise, and obtained approval to modify Specific Aim 3 to focus on the response to Heat Shock profiling male and female mice, separately.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2017
Accession Number
AD1043141

Entities

People

  • Ronna Hertzano

Organizations

  • University of Maryland, Baltimore

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cells
  • Data Analysis
  • Deafness
  • Department Of Defense
  • Ear
  • Ear Diseases
  • Experimental Design
  • Gene Expression
  • Hearing Disorders
  • Hearing Loss
  • Intellectual Property
  • Medical Personnel
  • Otorhinolaryngology
  • Professional Development
  • Therapy
  • Training

Readers

  • Auditory Neuroscience/Auditory Physiology.
  • Molecular and genetic basis of cancer.