Synergistic Interactions of Neuroprotective and Neurotrophic Factors Against Sleep Deprivation

Abstract

Sleep deprivation is one of the most common stressors that Airmen face during military missions. Exposure to this stressor will diminish performance increase the risk of make mistakes during critical assignments. Previous investigations have suggested that damaging brain effect of sleep deprivation may be caused by accumulation of reactive oxidant species, triggered by the decrease in the antioxidant defense and malfunction of the endoplasm reticulum (ER) molecular chaperones, and consequently, causing an increase in neuronal cell death.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2017
Accession Number
AD1043281

Entities

People

  • Amber Braddock
  • Amy D. Walters
  • Armando Soto
  • David A. Dixon
  • Jonathon Soto
  • Levaugh C Grant
  • Nicholas J. Delraso
  • Nicholas V. Reo
  • Renell H. Capati
  • Victor T. Chan

Tags

DTIC Thesaurus Topics

  • Body Weight
  • Brain
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Cognition
  • Cytoskeleton
  • Free Radicals
  • Gene Expression
  • Neurodegeneration
  • Neuroglia
  • Neurons
  • Neurosciences
  • Proteins
  • Stem Cells

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