Clinical Evaluation of Decellularized Nerve Allograft with Autologous Bone Marrow Stem Cells to Improve Peripheral Nerve Repair and Functional Outcomes

Abstract

The purpose of this study is to evaluate the safety of the nerve allograft and BMSC sequentially to repair peripheral nerve gaps of the ulnar and median nerves of the upper extremities between 2 and 7 centimeters (cm) in length. Subjects will be followed for 18months post-surgery. Secondary outcomes will be examined to evaluate the efficacy of the co-treatment for nerve repair compared to Avance Nerve Graft and BMSC treatments alone. The study is designed to treat up to 24 patients using the sequential treatment of nerve allograft and BMSC. This is a prospective, observational trial to evaluate the safety of Avance nerve graft and BMSC and to measure the efficacy of the synergistic treatment for peripheral nerve repair.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2017
Accession Number
AD1043377

Entities

People

  • Leon Nesti

Organizations

  • Henry M. Jackson Foundation for the Advancement of Military Medicine

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Allografts
  • Bone Marrow
  • Bones
  • Cells
  • Peripheral Nervous System
  • Sciatic Nerve
  • Stem Cells
  • Stromal Cells
  • Surgery
  • Test And Evaluation
  • Upper Extremity

Fields of Study

  • Medicine

Readers

  • Neuroscience
  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Biotechnology