Genetic Modeling of Radiation Injury in Prostate Cancer Patients Treated with Radiotherapy

Abstract

From the completed analyses performed during the first year of the project, we have identified eleven SNPs that show an association with two-year toxicity following prostate cancer radiotherapy. Three of these single nucleotide polymorphisms (SNPs) meet the stringent threshold for genome-wide significance (meta-p-value < 5x10-8), and eight others approached genome-wide significance. For the three genome-wide significant SNPs, we found that the direction of the effect was consistent across all studies for which data were available.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2017
Accession Number
AD1043390

Entities

People

  • Barry S. Rosenstein
  • Harry Ostrer

Organizations

  • Icahn School of Medicine at Mount Sinai

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Data Analysis
  • Data Management
  • Genetics
  • Information Science
  • Machine Learning
  • Medical Personnel
  • Neoplasms
  • Nucleotides
  • Prostate
  • Prostate Cancer
  • Radiation Oncology
  • Radiotherapy
  • Risk
  • Statistical Analysis
  • Therapy
  • Toxicity
  • Training

Fields of Study

  • Biology
  • Physics

Readers

  • Mathematics or Statistics
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology