Advanced Development of Gamma-Tocotrienol as a Radiation Countermeasure

Abstract

During the second year of the project, we completed all analyses for the pharmacokinetic study with gamma-tocotrienol (GT3) in four NHPs. Specifically, we completed subtask 3, 4, and 5 of major task 1 and 2. PK analysis of GT3 serum revealed results consistent with that with a previous PK study conducted in the PIs lab with GT3 of DTRA project. In addition, subtask 1 of major task 3 was completed during this reporting period. We collected and analyzed samples for complete blood counts, blood biochemistry, cytokine profile, citrulline, flow cytometric phenotyping of hematopoietic cells and gastrointestinal studies. We have completed one cohort of subtask 2 and anticipate to begin a second cohort of NHPs in order to complete subtask 2 in the very near future. Overall, project is progressing well.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2017
Accession Number
AD1043825

Entities

People

  • Vijay Singh

Organizations

  • Henry M. Jackson Foundation for the Advancement of Military Medicine

Tags

DTIC Thesaurus Topics

  • Biochemistry
  • Blood
  • Blood Cells
  • Bone Marrow Cells
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Granulocytes
  • Health Services
  • Hematopoietic Cells
  • Intellectual Property
  • Medical Personnel
  • Vitamin E

Readers

  • Aerial Delivery - Logistics and Supply Chain Management.
  • Technical Research and Report Writing.
  • Virology (or Medical Virology).